The following is a list of independent published research concerning the potential health benefits of Caffeic Acid. Abstracts are available by emailing sales@coffeeberry.org.

Caffeic Acid Studies

1. Phytomedicine. 2004 Jul;11(5):424-30 Studies on the protective effects of caffeic acid and quercetin on chemical-induced hepatotoxicity in rodents.Janbaz KH, Saeed SA, Gilani AH.

2. Int J Mol Med. 2004 Aug;14(2):305-10 Differentiation of HL-60 myeloid leukemia cells induced by all-trans retinoic acid is enhanced in combination with caffeic acid. Veselska R, Zitterbart K, Auer J, Neradil J.

3. Anticancer Res. 2004 Mar-Apr;24(2B):743-5 Plant phenolics protect from bleomycin-induced oxidative stress and mutagenicity in Salmonella typhimurium TA102. Stagos D, Kouris S, Kouretas D.

4. J Agric Food Chem. 2004 May 5;52(9):2518-26 Transepithelial transport of chlorogenic acid, caffeic acid, and their colonic metabolites in intestinal caco-2 cell monolayers. Konishi Y, Kobayashi S.

5. Breast Cancer Res. 2004;6(2):R63-R74. Epub 2003 Dec 15 Antiproliferative and apoptotic effects of selective phenolic acids on T47D human breast cancer cells: potential mechanisms of action.Kampa M, Alexaki VI, Notas G, Nifli AP, Nistikaki A, Hatzoglou A, Bakogeorgou E, Kouimtzoglou E, Blekas G, Boskou D, Gravanis A, Castanas E.

6. Beijing Da Xue Xue Bao. 2004 Feb;36(1):27-30 [Caffeic acid (CA) protects cerebellar granule neurons (CGNs) from apoptosis induced by neurotoxin 1-methyl-4-phenylpyridnium (MPP+)][Article in Chinese]Tian XF, Pu XP.

7. Folia Biol (Praha). 2003;49(5):197-202UVC-protective effect of caffeic acid on normal and transformed human skin cells in vitro.Neradil J, Veselska R, Slanina J.

8. J Pharm Pharmacol. 2003 Jul;55(7):1021-7Hypochlorite scavenging activity of hydroxycinnamic acids evaluated by a rapid microplate method based on the measurement of chloramines.Firuzi O, Giansanti L, Vento R, Seibert C, Petrucci R, Marrosu G, Agostino R, Saso L.

9. Pharmacol Biochem Behav. 2003 Jun;75(3):635-43Pharmacological evidence for antidementia effect of Choto-san (Gouteng-san), a traditional Kampo medicine.Watanabe H, Zhao Q, Matsumoto K, Tohda M, Murakami Y, Zhang SH, Kang TH, Mahakunakorn P, Maruyama Y, Sakakibara I, Aimi N, Takayama H.

10. Neuroreport. 2003 May 23;14(7):1067-70 Caffeic acid produces antidepressive- and/or anxiolytic-like effects through indirect modulation of the alpha 1A-adrenoceptor system in mice.Takeda H, Tsuji M, Miyamoto J, Masuya J, Iimori M, Matsumiya T.

11. Mutat Res. 2003 Jun 19;527(1-2):27-36 Ability of antioxidants to prevent oxidative mutations in Salmonella typhimurium TA102. Grey CE, Adlercreutz P.

12. Horm Metab Res. 2003 Apr;35(4):251-8 Release of beta-endorphin by caffeic acid to lower plasma glucose in streptozotocin-induced diabetic rats. Cheng JT, Liu IM, Tzeng TF, Chen WC, Hayakawa S, Yamamoto T.

13. . Food Addit Contam. 2003 May;20(5):490-3Naturally occurring phenols: a detoxification strategy for fumonisin B1.Beekrum S, Govinden R, Padayachee T, Odhav B.

14. . J Nutr. 2003 Jun;133(6):1853-9 Chlorogenic acid bioavailability largely depends on its metabolism by the gut microflora in rats.Gonthier MP, Verny MA, Besson C, Remesy C, Scalbert A.

15. Yao Xue Xue Bao. 2002 Jun;37(6):405-8. Related Articles, Links [Synergistic antitumor effect of sodium caffeate and mitomycin][Article in Chinese]Xu F, Song DQ, Zhen YS.

16. Psychopharmacology (Berl). 2002 Nov;164(2):233-5. Epub 2002 Sep 13Rosmarinic acid and caffeic acid reduce the defensive freezing behavior of mice exposed to conditioned fear stress.Takeda H, Tsuji M, Miyamoto J, Matsumiya T.

17. J Agric Food Chem. 2002 Sep 25;50(20):5735-41Absorption of phenolic acids in humans after coffee consumption.Nardini M, Cirillo E, Natella F, Scaccini C.

18. Int J Tissue React. 2002;24(2):53-6 Inhibitory activity of the white wine compounds, tyrosol and caffeic acid, on lipopolysaccharide-induced tumor necrosis factor-alpha release in human peripheral blood mononuclear cells.Giovannini L, Migliori M, Filippi C, Origlia N, Panichi V, Falchi M, Bertelli AA, Bertelli A.

19. Eur J Pharmacol. 2002 Aug 9;449(3):261-7 Rosmarinic acid and caffeic acid produce antidepressive-like effect in the forced swimming test in mice.Takeda H, Tsuji M, Inazu M, Egashira T, Matsumiya T.

20. Yakugaku Zasshi. 2002 Jul;122(7):487-94 [Identification of chemical structure of antibacterial components against Legionella pneumophila in a coffee beverage] [Article in Japanese]Dogasaki C, Shindo T, Furuhata K, Fukuyama M.

21. Biomed Pharmacother. 2002 Jun;56(4):200-7Polyphenols: do they play a role in the prevention of human pathologies?Tapiero H, Tew KD, Ba GN, Mathe G.

22. Planta Med. 2002 Jun;68(6):483-6 Effect of caffeic acid on apical transporters' dysfunction of renal proximal tubule cells under oxidative stress in vitro.Han HJ, Park SH, Park KM, Yoon BC, Kim TS, Lee JH.

23. Ann N Y Acad Sci. 2002 May;957:295-301 Oxidative stress and inflammatory reaction modulation by white wine.Bertelli AA, Migliori M, Panichi V, Longoni B, Origlia N, Ferretti A, Cuttano MG, Giovannini L.

24. Ann N Y Acad Sci. 2002 May;957:90-102 Inhibition by wine polyphenols of peroxynitrite-initiated chemiluminescence and NADH oxidation.Boveris A, Valdez L, Alvarez S.

25. . Drugs Exp Clin Res. 2002;28(1):11-5 Effect of some white wine phenols in preventing inflammatory cytokine release.Bertelli A, Migliori M, Bertelli AA, Origlia N, Filippi C, Panichi V, Falchi M, Giovannini L.

26. J Agric Food Chem. 2002 Jun 19;50(13):3660-7 Determination of free and total phenolic acids in plant-derived foods by HPLC with diode-array detection.Mattila P, Kumpulainen J.

27. . Free Radic Res. 2002 Jan;36(1):113-8Effects of dietary antioxidants on human DNA ex vivo.Szeto YT, Benzie IF.

28. Hypertens Res. 2002 Jan;25(1):99-107 Green coffee bean extract and its metabolites have a hypotensive effect in spontaneously hypertensive rats.Suzuki A, Kagawa D, Ochiai R, Tokimitsu I, Saito I.

29. Folia Microbiol (Praha). 2001;46(6):511-4 Phenolic acids reduce the genotoxicity of acridine orange and ofloxacin in Salmonella typhimurium.Belicova A, Krizkova L, Nagy M, Krajcovic J, Ebringer L.

30. J Org Chem. 2002 Feb 8;67(3):803-10 New insights into the acid-promoted reaction of caffeic acid and its esters with nitrite: decarboxylation drives chain nitrosation pathways toward novel oxime derivatives and oxidation/fragmentation products thereof.Napolitano A, d'Ischia M.

31. Mol Cell Biochem. 2001 Oct;226(1-2):89-95 Plant catechols prevent lipid peroxidation in human plasma and erythrocytes.Lekse JM, Xia L, Stark J, Morrow JD, May JM.

32. Lipids. 2001 Oct;36(10):1111-6 Antioxidative activity of 3,4-dihydroxyphenylacetic acid and caffeic acid in rat plasma.Raneva V, Shimasaki H, Ishida Y, Ueta N, Niki E.

33. J Environ Sci Health Part A Tox Hazard Subst Environ Eng. 2001;36(10):1891-904. Chemical kinetics of the photocatalytic degradation of trans-cinnamic, dihydrocinnamic, trans-caffeic, and dihydrocaffeic acids.Grimes SM, Mehta LK, Ngwang HC.

34. J Appl Toxicol. 2001 Nov-Dec;21(6):527-31 Structure-hepatoprotective activity relationship of 3,4-dihydroxycinnamic acid (caffeic acid) derivatives.Perez-Alvarez V, Bobadilla RA, Muriel P.

35. J Agric Food Chem. 2001 Dec;49(12):5964-8Plasma levels of caffeic acid and antioxidant status after red wine intake.Simonetti P, Gardana C, Pietta P.

36. . Food Chem Toxicol. 2001 Dec;39(12):1205-10Effect of natural phenolic acids on DNA oxidation in vitro.Lodovici M, Guglielmi F, Meoni M, Dolara P.

37. J Neurosci Res. 2001 Sep 15;65(6):565-72Involvement of the 5-lipoxygenase pathway in the neurotoxicity of the prion peptide PrP106-126.Stewart LR, White AR, Jobling MF, Needham BE, Maher F, Thyer J, Beyreuther K, Masters CL, Collins SJ, Cappai R.

38. . J Environ Sci Health Part A Tox Hazard Subst Environ Eng. 2001 May;36(5):599-612 Photocatalytic degradation of trans-cinnamic, dihydrocinnamic, trans-caffeic, and dihydrocaffeic acids and characterization of the products.Grimes SM, Mehta LK, Ngwang HC.

39. Planta Med. 2001 Jun;67(4):322-5 Studies on the hepatocyte protective activity and the structure-activity relationships of quinic acid and caffeic acid derivatives from the flower buds of Lonicera bournei.Xiang T, Xiong QB, Ketut AI, Tezuka Y, Nagaoka T, Wu LJ, Kadota S.

40. Skin Res Technol. 2000 Nov;6(4):199-204 Tonality of suntan vs sunless tanning with dihydroxyacetone. Muizzuddin N, Marenus KD, Maes DH

41. Br J Pharmacol. 2001 Apr;132(8):1777-88Phenolic antioxidants trolox and caffeic acid modulate the oxidized LDL-induced EGF-receptor activation.Vacaresse N, Vieira O, Robbesyn F, Jurgens G, Salvayre R, Negre-Salvayre A.

42. J Nutr. 2001 Jan;131(1):66-71 Chlorogenic acid and caffeic acid are absorbed in humans. Olthof MR, Hollman PC, Katan MB.

43. . Biochem Biophys Res Commun. 2000 Dec 20;279(2):692-9 A reevaluation of the peroxynitrite scavenging activity of some dietary phenolics.Ketsawatsakul U, Whiteman M, Halliwell B.

44. Z Naturforsch [C]. 2000 Sep-Oct;55(9-10):814-9 Effect of minor components of virgin olive oil on topical antiinflammatory assays.de la Puerta R, Martinez-Dominguez E, Ruiz-Gutierrez V.

45. J Agric Food Chem. 2000 Nov;48(11):5496-500 Absorption of chlorogenic acid and caffeic acid in rats after oral administration.Azuma K, Ippoushi K, Nakayama M, Ito H, Higashio H, Terao J.

46. Med Clin (Barc). 2000 Jul 1;115(5):166-9 [Olive oil and inhibition of low density lipoprotein oxidation. Role of phenolic compounds] [Article in Spanish]Fito M, Covas MI, Lamuela-Raventos RM, Vila J, de la Torre C, Marrugat J.

47. . Naunyn Schmiedebergs Arch Pharmacol. 2000 Aug;362(2):122-7Stimulatory effect of caffeic acid on alpha1A-adrenoceptors to increase glucose uptake into cultured C2C12 cells. Cheng JT, Liu IM.

48. Redox Rep. 2000;5(2-3):124-5 Phenolic acids protect low density lipoproteins from peroxynitrite-mediated modification in vitro.Morton LW, Croft KD, Puddey IB, Byrne L.

49. Lipids. 2000 Jun;35(6):633-8 Protective effect of olive oil and its phenolic compounds against low density lipoprotein oxidation.Fito M, Covas MI, Lamuela-Raventos RM, Vila J, Torrents L, de la Torre C, Marrugat J.

50. Planta Med. 2000 Apr;66(3):228-30 Caffeic acid as active principle from the fruit of Xanthium strumarium to lower plasma glucose in diabetic rats.Hsu FL, Chen YC, Cheng JT.

51. Free Radic Res. 2000 Jun;32(6):549-59 Comparison of the phenolic composition of fruit juices by single step gradient HPLC analysis of multiple components versus multiple chromatographic runs optimised for individual families.Bremner PD, Blacklock CJ, Paganga G, Mullen W, Rice-Evans CA, Crozier A.

52. Int J Pharm. 2000 Apr 10;199(1):39-47 In vitro and in vivo evaluation of caffeic and ferulic acids as topical photoprotective agents.Saija A, Tomaino A, Trombetta D, De Pasquale A, Uccella N, Barbuzzi T, Paolino D, Bonina F.

53. . Biochim Biophys Acta. 2000 Apr 6;1474(2):219-25 In vitro inhibition of the activity of phosphorylase kinase, protein kinase C and protein kinase A by caffeic acid and a procyanidin-rich pine bark (Pinus marittima) extract.Nardini M, Scaccini C, Packer L, Virgili F.

54. Proc West Pharmacol Soc. 1999;42:17-8 Dose-regimen dependent caffeic acid prevention of acute liver damage.Perez-Alvarez V, Bobadilla RA, Alias A, Rico M, Muriel P.

55. Arzneimittelforschung. 2000 Jan;50(1):72-6 Effect of quercetin, caffeic acid and caffeic acid phenylethyl ester, solubilized in non-ionic surfactants, on histamine release in vivo and in vitro.Scheller S, Dworniczak S, Pogorzelska T, Rajca M, Shani J.

56. Curr Pharm Des. 1999 Jan;5(1):11-20 15-Lipoxygenase and its inhibition: a novel therapeutic target for vascular disease.Cornicelli JA, Trivedi BK.

57. Biochem Pharmacol. 1999 Feb 15;57(4):445-9 Inhibition of leukocyte 5-lipoxygenase by phenolics from virgin olive oil.de la Puerta R, Ruiz Gutierrez V, Hoult JR.

58. Nutr Cancer. 1998;32(2):81-5 Polyphenols inhibit promotional phase of tumorigenesis: relevance of superoxide radicals.Kaul A, Khanduja KL.

59. Free Radic Biol Med. 1998 Dec;25(9):1098-105 Effect of caffeic acid on tert-butyl hydroperoxide-induced oxidative stress in U937.Nardini M, Pisu P, Gentili V, Natella F, Di Felice M, Piccolella E, Scaccini C.

60. J Pharm Pharmacol. 1998 Oct;50(10):1183-6 Anti-inflammatory activity in rats and mice of phenolic acids isolated from Scrophularia frutescens.Fernandez MA, Saenz MT, Garcia MD.

61. Bioorg Med Chem. 1998 Jul;6(7):1051-6 Antiallergic activities of rabdosiin and its related compounds: chemical and biochemical evaluations.Ito H, Miyazaki T, Ono M, Sakurai H.

62. Microbios. 1998;93(374):43-54 Comparative antibacterial and antifungal effects of some phenolic compounds.Aziz NH, Farag SE, Mousa LA, Abo-Zaid MA.

63. Carcinogenesis. 1997 Sep;18(9):1729-38 Mechanism of action of dietary chemoprotective agents in rat liver: induction of phase I and II drug metabolizing enzymes and aflatoxin B1 metabolism.Manson MM, Ball HW, Barrett MC, Clark HL, Judah DJ, Williamson G, Neal GE.

64. Biochim Biophys Acta. 1997 Jun 6;1335(3):335-42 Antioxidant activity of polyphenolics in diets. Rate constants of reactions of chlorogenic acid and caffeic acid with reactive species of oxygen and nitrogen.Kono Y, Kobayashi K, Tagawa S, Adachi K, Ueda A, Sawa Y, Shibata H.

65. Arch Biochem Biophys. 1997 Jun 1;342(1):157-60 Effect of caffeic acid dietary supplementation on the antioxidant defense system in rat: an in vivo study.Nardini M, Natella F, Gentili V, Di Felice M, Scaccini C.

66. Anticancer Res. 1997 May-Jun;17(3C):1913-7 Chemosensitizing activity of caffeic acid in multidrug-resistant MCF-7/Dox human breast carcinoma cells.Ahn CH, Choi WC, Kong JY.

66. Clin Sci (Lond). 1996 Oct;91(4):449-58 Phenolic content of various beverages determines the extent of inhibition of human serum and low-density lipoprotein oxidation in vitro: identification and mechanism of action of some cinnamic acid derivatives from red wine.Abu-Amsha R, Croft KD, Puddey IB, Proudfoot JM, Beilin LJ.

67. J Chromatogr A. 1996 Aug 16;741(2):223-31Determination of some pharmacologically active phenolic acids in juices by high-performance liquid chromatography.Shahrzad S, Bitsch I.

68. Biosci Biotechnol Biochem. 1996 Feb;60(2):328-9 Antimutagenic activity of caffeic acid and related compounds.Yamada J, Tomita Y.

69. Food Chem Toxicol. 1996 Jan;34(1):15-20 Anti-genotoxic effects in mice after the interaction between coffee and dietary constituents.Abraham SK.

70. J Chromatogr B Biomed Appl. 1995 Nov 3;673(1):43-9 Determination of caffeic acid in rabbit plasma by high-performance liquid chromatography.Uang YS, Kang FL, Hsu KY.

71. Free Radic Biol Med. 1995 Nov;19(5):541-52 Inhibition of human low-density lipoprotein oxidation by caffeic acid and other hydroxycinnamic acid derivatives.Nardini M, D'Aquino M, Tomassi G, Gentili V, Di Felice M, Scaccini C.

72. J Nat Prod. 1995 Mar;58(3):392-400 Anti-AIDS agents, 18. Sodium and potassium salts of caffeic acid tetramers from Arnebia euchroma as anti-HIV agents.Kashiwada Y, Nishizawa M, Yamagishi T, Tanaka T, Nonaka G, Cosentino LM, Snider JV, Lee K.

73. Biochem Pharmacol. 1994 Aug 3;48(3):487-94 Reactivity of dietary phenolic acids with peroxyl radicals: antioxidant activity upon low density lipoprotein peroxidation.Laranjinha JA, Almeida LM, Madeira VM.

74. Cancer Res. 1994 Apr 1;54(7 Suppl):1991s-1993s Suppression of hydroperoxide-induced cytotoxicity by polyphenols.Nakayama T.
75. Biomed Environ Sci. 1994 Mar;7(1):68-78 The blocking effect of phenolic acid on N-nitrosomorpholine formation in vitro.Li P, Wang HZ, Wang XQ, Wu YN.

76. . FEBS Lett. 1993 Aug 23;329(1-2):21-4Caffeic acid phenethyl ester as a lipoxygenase inhibitor with antioxidant properties.Sud'ina GF, Mirzoeva OK, Pushkareva MA, Korshunova GA, Sumbatyan NV, Varfolomeev SD.

77. Cancer Res. 1993 Mar 15;53(6):1255-61Inhibition of tumor promoter-mediated processes in mouse skin and bovine lens by caffeic acid phenethyl ester.Frenkel K, Wei H, Bhimani R, Ye J, Zadunaisky JA, Huang MT, Ferraro T, Conney AH, Grunberger D.

78. . Mutat Res. 1989 Dec;215(2):223-34Reactive oxygen-mediated damage to murine mammary tumor cells.Paul LA, Fulton AM, Heppner GH.

79. Adv Cancer Res. 1989;53:247-302 Antioxidants--carcinogenic and chemopreventive properties. Ito N, Hirose M.